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KMID : 0861120230270020023
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Korean Journal of Oriental Preventive Medicine
2023 Volume.27 No. 2 p.23 ~ p.33
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Relieving effect for respiratory inflammation of Sojadodamgangki-tang
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Han Youn-Ji
Seon Chang-Woo
Woo Yeon-Ju
Lee Dong-Hyuk
Suh Jin-Woo
Yu Jun-Sang
Kim Joo-Hee
Kwon Bo-In
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Abstract
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Objectives : Sojadodamgangki-tang and its main components are traditional korean medicinal methods for treatment of cough, sputum and dyspnea. Using a respiratory inflammatory model, we intend to reveal the anti-inflammatory effect and its immune mechanism of Sojadodamgangki-tang.
Methods : We used a papain-induced respiratory inflammatory mouse model. 8-week-old female BALB/C mice were divided into 3 groups as follows: the following groups: saline control group, papain treated group (vehicle), papain and Sojadodamgangki-tang (200 mg/kg) treated group(n=4). To evaluate the anti-inflammatory effect of Sojadodamgangki-tang extracts, inflammatory cell infiltration was measured in bronchoalveolar lavage fluid (BALF) and nasal lavage fluid (NALF). In addition, the effects of Sojadodamgangki-tang extracts on Th2 cell population in lung were determined by using flow cytometry.
Results : Sojadodamgangki-tang extracts administration reduced inflammatory cell infiltration in BALF and NALF, especially of eosinophils. Furthermore, total immunogloblin (Ig)-E levels was reduced in BALF and serum by drug administration. Interestingly, Sojadodamgangki-tang extracts treatment also decreased the Th2 cell (CD4+ GATA3+ ) population in lung.
Conclusions : Our findings indicate Sojadodamgangki-tang extracts have anti-inflammatory effects by mediating Th2 cell and B cell activation.
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KEYWORD
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Sojadodamgangki-tang, Respiratory inflammation, Immunogloblin-E, Th2 cell
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